解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates1,2. After birth, these infants are at high risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regulation, and can develop a severe condition called...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0436-0
更新日期:2019-05-01 00:00:00
abstract::Overexpression of the B7-H1 (PD-L1) molecule in the tumor microenvironment (TME) is a major immune evasion mechanism in some patients with cancer, and antibody blockade of the B7-H1/PD-1 interaction can normalize compromised immunity without excessive side-effects. Using a genome-scale T cell activity array, we identi...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0374-x
更新日期:2019-04-01 00:00:00
abstract:: ...
journal_title:Nature medicine
pub_type: 评论,杂志文章
doi:10.1038/s41591-019-0397-3
更新日期:2019-03-01 00:00:00
abstract::In the version of this article originally published, there was an error in the legend for Extended Data Fig. 7. The legend for panel f was originally: "f, FACS analysis of IL7R-, CD62L- and CD45RA- expression on TRAC-1928ζ and TRAC-1XX CAR T cells at day 63 post CAR infusion (representative for at least n = 3 mice per...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-019-0360-3
更新日期:2019-03-01 00:00:00
abstract::The molecular alterations that occur in cells before cancer is manifest are largely uncharted. Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell carcinoma. Although microscopically identical, their future is in equipoise, with half progressing to invasive cancer and half regressing o...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0323-0
更新日期:2019-03-01 00:00:00
abstract::Hutchinson-Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. Here we show that reduction ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0343-4
更新日期:2019-03-01 00:00:00
abstract::Glioblastoma is the most common primary central nervous system malignancy and has a poor prognosis. Standard first-line treatment, which includes surgery followed by adjuvant radio-chemotherapy, produces only modest benefits to survival1,2. Here, to explore the feasibility, safety and immunobiological effects of PD-1 ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0339-5
更新日期:2019-03-01 00:00:00
abstract::Major depressive disorder is a devastating psychiatric disease that afflicts up to 17% of the world's population. Postmortem brain analyses and imaging studies of patients with depression have implicated basal lateral amygdala (BLA) dysfunction in the pathophysiology of depression. However, the circuit and molecular m...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0299-9
更新日期:2019-02-01 00:00:00
abstract::Photoreceptor ciliopathies constitute the most common molecular mechanism of the childhood blindness Leber congenital amaurosis. Ten patients with Leber congenital amaurosis carrying the c.2991+1655A>G allele in the ciliopathy gene centrosomal protein 290 (CEP290) were treated (ClinicalTrials.gov no. NCT03140969 ) wit...
journal_title:Nature medicine
pub_type: 临床试验,杂志文章
doi:10.1038/s41591-018-0295-0
更新日期:2019-02-01 00:00:00
abstract:: ...
journal_title:Nature medicine
pub_type: 评论,杂志文章
doi:10.1038/s41591-019-0362-1
更新日期:2019-02-01 00:00:00
abstract:: ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0350-5
更新日期:2019-02-01 00:00:00
abstract::Computerized electrocardiogram (ECG) interpretation plays a critical role in the clinical ECG workflow1. Widely available digital ECG data and the algorithmic paradigm of deep learning2 present an opportunity to substantially improve the accuracy and scalability of automated ECG analysis. However, a comprehensive eval...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0268-3
更新日期:2019-01-01 00:00:00
abstract:: ...
journal_title:Nature medicine
pub_type: 评论,杂志文章
doi:10.1038/s41591-018-0332-z
更新日期:2019-01-01 00:00:00
abstract::Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites1. However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intrinsically tumor rea...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0266-5
更新日期:2019-01-01 00:00:00
abstract::In the version of this article originally published, an author was missing from the author list. Alexander J. Lazar should have been included between Jorge M. Blando and James P. Allison. The author has been added to the list, and the author contributions section has been updated to include Alexander J. Lazar's contri...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-018-0305-2
更新日期:2019-01-01 00:00:00
abstract::In the version of this article originally published, there was an error in Fig. 2b. RECIST ORR and pCR were both listed as 25%. RECIST ORR was actually 73%, and pCR was 45%. Also, an author's name was incorrect in the author list. Danny K. Wells should have been listed as Daniel K. Wells. The errors have been correcte...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-018-0251-z
更新日期:2018-12-01 00:00:00
abstract:: ...
journal_title:Nature medicine
pub_type: 评论,杂志文章
doi:10.1038/s41591-018-0286-1
更新日期:2018-12-01 00:00:00
abstract::In the version of this article originally published, Dimitry G. Sayenko's affiliations were not correct. The following affiliation for this author was missing: Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA. This affiliation has been added for the autho...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-018-0248-7
更新日期:2018-12-01 00:00:00
abstract::Peripheral nerve injuries represent a significant problem in public health, constituting 2-5% of all trauma cases1. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function2. Numerous studies report the potential of pharmacologica...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0196-2
更新日期:2018-12-01 00:00:00
abstract::Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1 expression is a potentia...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0217-1
更新日期:2018-12-01 00:00:00
abstract::Hematopoietic stem and progenitor cells (HSPC) are endowed with the role of generating and maintaining lifelong the extremely diverse pool of blood cells1. Clinically, transplantation of human HSPC from an allogeneic healthy donor or infusion of autologous gene-corrected HSPC can effectively replenish defective blood ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0195-3
更新日期:2018-11-01 00:00:00
abstract::Spinal sensorimotor networks that are functionally disconnected from the brain because of spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore robust, coordinated motor activity in humans with paralysis1-3. Previously, we reported a clinical case of complete sensorimotor par...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0175-7
更新日期:2018-11-01 00:00:00
abstract::In the version of this article originally published, a grant was omitted from the Acknowledgements section. The following sentence should have been included: "R.B.M. was supported by a Department of Veterans Affairs Merit Award (5I01BX003272)." The error has been corrected in the HTML and PDF versions of this article....
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-018-0170-z
更新日期:2018-10-01 00:00:00
abstract::In the Supplementary Information originally published with this article, a lane was missing in the β-actin blot in Supplementary Fig. 2. The lane has been added. The error has been corrected in the Supplementary Information associated with this article. ...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-018-0168-6
更新日期:2018-10-01 00:00:00
abstract::Although programmed death-ligand 1-programmed death 1 (PD-L1-PD-1) inhibitors are broadly efficacious, improved outcomes have been observed in patients with high PD-L1 expression or high tumor mutational burden (TMB). PD-L1 testing is required for checkpoint inhibitor monotherapy in front-line non-small-cell lung canc...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0134-3
更新日期:2018-09-01 00:00:00
abstract::Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs)...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0116-5
更新日期:2018-08-01 00:00:00
abstract::Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive age-related pathology and be therapeutically targeted is still unclear...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0092-9
更新日期:2018-08-01 00:00:00
abstract::There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD), paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum of liver abnormalities from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but can lead to cirrhosi...
journal_title:Nature medicine
pub_type: 杂志文章,评审
doi:10.1038/s41591-018-0104-9
更新日期:2018-07-01 00:00:00
abstract::It has long been assumed that p53 suppresses tumor development through induction of apoptosis, possibly with contributions by cell cycle arrest and cell senescence1,2. However, combined deficiency in these three processes does not result in spontaneous tumor formation as observed upon loss of p53, suggesting the exist...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0043-5
更新日期:2018-07-01 00:00:00
abstract::Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosphorylation (OXPHOS) has remained largely unexplored, partly owing to a...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0052-4
更新日期:2018-07-01 00:00:00
abstract::The role of KRAS, when activated through canonical mutations, has been well established in cancer1. Here we explore a secondary means of KRAS activation in cancer: focal high-level amplification of the KRAS gene in the absence of coding mutations. These amplifications occur most commonly in esophageal, gastric and ova...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0022-x
更新日期:2018-07-01 00:00:00
abstract::We describe results from IMmotion150, a randomized phase 2 study of atezolizumab (anti-PD-L1) alone or combined with bevacizumab (anti-VEGF) versus sunitinib in 305 patients with treatment-naive metastatic renal cell carcinoma. Co-primary endpoints were progression-free survival (PFS) in intent-to-treat and PD-L1+ pop...
journal_title:Nature medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/s41591-018-0053-3
更新日期:2018-06-01 00:00:00
abstract::Sphingosine-1-phosphate (S1P) signaling influences bone metabolism, but its therapeutic potential in bone disorders has remained unexplored. We show that raising S1P levels in adult mice through conditionally deleting or pharmacologically inhibiting S1P lyase, the sole enzyme responsible for irreversibly degrading S1P...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0005-y
更新日期:2018-05-01 00:00:00
abstract::Spinal bulbar muscular atrophy (SBMA) is a motor neuron disease caused by toxic gain of function of the androgen receptor (AR). Previously, we found that co-regulator binding through the activation function-2 (AF2) domain of AR is essential for pathogenesis, suggesting that AF2 may be a potential drug target for selec...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4500
更新日期:2018-05-01 00:00:00
abstract::This corrects the article DOI: 10.1038/nm.4439. ...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/nm0418-526b
更新日期:2018-04-10 00:00:00
abstract::The adoptive transfer of T cells engineered with a chimeric antigen receptor (CAR) (hereafter referred to as CAR-T cells) specific for the B lymphocyte antigen CD19 has shown impressive clinical responses in patients with refractory B cell malignancies. However, the therapeutic effects of CAR-T cells that target other...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4478
更新日期:2018-03-01 00:00:00
abstract::Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. We recently described a novel, near-physiological organoid culture system, wherein primary human healthy liver cells form long-term expanding organoids that retain liver tissue functi...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4438
更新日期:2017-12-01 00:00:00
abstract::Cancer-specific cell-surface antigens are ideal targets for monoclonal antibody (mAb)-based immunotherapy but are likely to have previously been identified in transcriptome or proteome analyses. Here, we show that the active conformer of an integrin can serve as a specific therapeutic target for multiple myeloma (MM)....
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4431
更新日期:2017-12-01 00:00:00
abstract::Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequently co-occur with those in KRAS, which themselves may lead to thera...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4407
更新日期:2017-11-01 00:00:00
abstract::Natural killer (NK) cells play an essential role in antiviral immunity, but knowledge of their function in secondary lymphoid organs is incomplete. Lymph node follicles constitute a major viral reservoir during infections with HIV-1 and simian immunodeficiency virus of macaques (SIVmac). In contrast, during nonpathoge...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4421
更新日期:2017-11-01 00:00:00